ZBRUSH 3.1 - WINDOWS
Recommended:

OS: Windows XP/Vista
CPU:
Fast P4 or newer (or equivalent such as AMD) with optional multithreading or hyperthreading capabilities
RAM:
1024MB (2048MB for working with multi-million-poly meshes)
Monitor:
1280x1024 monitor resolution or higher (32 bits)

Minimum System Requirements
OS:
Windows 2000
CPU:
PIII
RAM: 512MB (1024 MB recommended)
Monitor: 1024x768 monitor resolution (32 bits)


ZBRUSH 3.12 - macintosh
Required:

OS: Mac OSX 10.5 or newer.
CPU: Intel Macintosh
RAM: 1024MB (2048MB recommended for working with multi-million-polys)
Monitor: 1024x768 monitor resolution set to Millions of Colors
(recommended: 1280 x 1024 or higher)


ZBRUSH 2 - macintosh
Recommended:

OS: Mac OSX 10.4 or newer.
CPU: Power PC
RAM: 1024MB (2048MB recommended)
Monitor: 1024x768 monitor resolution set to Millions of Colors